​信州大学農学部　農学生命科学科　生命機能科学コース
食品機能学研究室

標的タンパク質に基づく食品成分の抗肥満効果ーメチルキサンチン類の新規作用ー.

化学と生物【解説】, 11月号. 2022年

Author: 三谷 塁一.

研究概要が「化学と生物」11月号の表紙に選ばれました.

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25-Hydroxyvitamin D increases insulin-stimulated glucose uptake by enhancing adipocyte differentiation.

J Nutr Sci Vitaminol, 68: 420-428, 2022 (Online published: 31 Oct. 2022).

Author: Nakashima M., Mitani T＊. (＊: corresponding author)

25-ヒドロキシビタミンDは脂肪細胞への分化を正に制御することで, Adiponectinの発現量と

インスリン刺激によるグルコースの取込み能を亢進することを見出した研究.

CiteScore rank: 150/276 (Medicine), 81/127 (Nutrition and Dietetics)

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Isolation, identification, and in vivo evaluation of the novel antihypertensive peptide, VSKRLNGDA, derived from chicken blood cells.

Process Biochemistry, 115:169-177, 2022 (Online published: 15 Feb. 2022).

Author: Wongngam W., Roytrakul S., Mitani T., Katayama S., Nakamur S., Yongsawatdigul J.

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Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the

mitochondria.

Bioscience, Biotechnology, and Biochemistry, 86:260-272, 2022 (Online published: 29 Nov. 2021).

Author: Ikeda T., Watanabe S., Mitani T＊. (＊: corresponding author)

ゲニステイン（大豆イソフラボン）が脂質形成を抑制する際の標的タンパク質を同定した研究.

研究概要がBiosci Biotechnol Biochem. 2022, volume 86, Issue 2の表紙に選ばれました.

研究内容が2022年度のBBB論文賞に選ばれました.

CiteScore rank: 68/130 (Analytical Chemistry), 160/293 (Biotechnology)

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Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner.

Journal of Nutritional Biochemistry, 100:108898, 2022. (Online published: 5 Nov. 2021).

Author: Tanaka E., Mitania T＊, Nakashima M., Yonemoto E., Fujii H., Ashida H. (＊: corresponding author)

テオブロミン（カカオ豆成分）の摂取がPPARγシグナル依存的に白色脂肪細胞の褐色化を促す研究.

CiteScore rank: 4/127 (Nutrition and Dietetics), 41/425 (Biochemistry)

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Production and characterization of chicken blood hydrolysate with antihypertensive properties.

Poultry Science, 99(10):5163-74, 2020.

Author: Wongngam W., Mitani T., Katayama S., Nakamura S., Yongsawatdigul J.

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Enzymatically synthesized glycogen prevents UVB-induced cell damage in normal human epidermal keratinocytes.
Journal of Clinical Biochemistry and Nutrition, 67(1):36-42, 2020.
Author: Yoshioka Y., Kitakaze T., Mitani T., Furuyasiki T., Ashida H.

Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes.
Biochemical and Biophysical Research Communications, 522(3):770-775, 2020. (Online published: 30 Nov. 2019).
Author: Mitani T＊., Watanabe S., Wada K., Fujii H., Nakamura S., Katayama S. (＊: corresponding author)

細胞内cAMPレベルの増加がC/EBPβを介してNAMPTの発現を誘導し、脂肪細胞の分化を制御する研究.

CiteScore rank: 29/137 (Biophysics), 144/425 (Biochemistry)

 

Oral immunotherapy with a phosphorylated hypoallergenic allergen ameliorates allergic responses more effectively than intact allergen in a murine model of buckwheat allergy.
Molecular Nutrition & Food Research, 62(21):e1800303, 2018.
Author: Katayama S., Yamaguchi D., Suzuki Y., Athamneh A.M.A., Mitani T., Satoh R., Teshima R., Mine Y., Nakamura S.

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Soybean-derived glycine-arginine dipeptide administration promotes neurotrophic factor expression in the mouse brain.
Journal of Agricultural and Food Chemistry, 66(30):7935-7941, 2018.
Author: Shimizu., A; Mitani T., Tanaka S., Fujii H., Maebuchi M., Amiya Y., Tanaka M., Matsui T., Nakamura S., Katayama S.

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Long-term diet supplementation with lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8.
Nutrients,10(6):E762, 2018.
Author: Corpuz H.M., Ichikawa S., Arimura M., Mihara T., Kumagai T., Mitani T., Nakamura S., Katayama S.

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Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes.
Archives of Biochemistry and Biophysics, 646:98-106, 2018.
Author: Mitani T., Takaya T., Harada N., Katayama S., Yamaji R., Nakamura S., Ashida H.

テオフィリン（茶葉の微量成分）がグルココルチコイド受容体と結合することIL-6の発現を抑制し, 高血糖状態を緩和する研究.

CiteScore rank: 26/137 (Biophysics), 130/425 (Biochemistry)

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Methylxanthine derivative-rich cacao extract suppresses differentiation of adipocytes through down-regulation of PPARγ and C/EBPs.
Journal of Nutritional Science and Vitaminology, 64(2):151-160, 2018.
Author: Yamashita Y*., Mitani T*., Wang L., Ashida H.　(*Co-first Author)

メチルキサンチンを豊富に含むカカオ豆抽出物が脂肪細胞の分化を抑制する研究.

CiteScore rank: 150/276 (Medicine), 81/127 (Nutrition and Dietetics)

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Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway.
Scientific Reports, 8(1):5625, 2018.
Author: Chawalitpong S., Chokchaisiri R., Suksamrarn A., Katayama S., Mitani T., Nakamura S., Athamneh A.A., Ritprajak P., Leelahavanichkul A., Aeimlapa R., Charoenphandhu N., Palaga T.

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Caffeine-stimulated intestinal epithelial cells suppress lipid accumulation in adipocytes.
Journal of Nutritional Science and Vitaminology, 63(5):333-340, 2017.
Author: Mitani T., Nagano T., Harada K., Yamashita Y., Ashida H.
カフェインによって刺激された腸管上皮細胞から分泌されたサイトカインが脂肪細胞の脂質蓄積を抑制する研究.
CiteScore rank: 150/276 (Medicine), 81/127 (Nutrition and Dietetics)

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Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein degradation by adenosine receptor A1.
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1864(12):2438-2448, 2017.
Author: Mitani T., Watanabe S., Yoshioka Y., Katayama S., Nakamura S., Ashida H.

テオブロミン（カカオ豆成分）がアデノシン受容体1に結合することでC/EBPβの分解を促し, その結果脂肪細胞の脂質形成を抑制する研究.

CiteScore rank: 109/386 (Molecular Biology), 83/274 (Cell Biology)

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Solventless extraction methods for immature fruits: evaluation of their antioxidant and cytoprotective activities
Food Chemistry, 221:1388-1393, 2017.
Author: Heng M.Y., Katayama S., Mitani T., Ong E.S., Nakamura S.

 

Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress.
Free Radical Biology and Medicine,106:355-367, 2017.
Author: Mitani T., Yoshioka Y., Furuyashiki T., Yamashita Y., Shirai Y., Ashida H.

酵素合成グリコーゲン摂取が抗酸化タンパク質の発現量を増加することで炎症性腸疾患を緩和する研究.

CiteScore rank: 33/425 (Biochemisry), 10/101 (Physiology)

 

Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells.
Journal of Clinical Biochemistry and Nutrition, 60(2):108-114, 2016.
Author: Yoshioka Y., Li X., Zhang T., Mitani T., Yasuda M., Nanba F., Toda T., Yamashita Y., Ashida H.
 

Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.
Scientific reports, 6:23001, 2016.
Author: Harada N., Hanaoka R., Horiuchi H., Kitakaze T., Mitani T., Inui H., Yamaji R.
 

Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia.
Cellular Signalling, 27(10):1994-2001, 2015.
Author: Mitani T., Minami M., Harada N., Ashida H., Yamaji R.

低酸素下でp62のリン酸化が増加することでアンドロゲン受容体の分解が進み, その結果前立腺がん細胞のアポトーシスが抑制される研究.

CiteScore rank: 91/274 (Cell Biology)

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多機能性を持つMoonlighting Proteins (特集 タンパク質・酵素の隠された機能について,探索とその技術)
生化学 ,87(3):279-285, 2015.
Author: 原田 直樹; 三谷 塁一; 山地 亮一

 

Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model.
Pesticide Biochemistry and Physiology, 120:14-20, 2015.
Author: Ashida H., Harada K., Mishima S., Mitani T., Yamashita Y., Matsumura F.

 

Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer.
Journal of Nutritional Science and Vitaminology, 60(4):276-282, 2014.
Author: Mitani T., Harada N., Tanimori S., Nakano Y., Inui H., Yamaji R.

レスベラトロール（ブドウ果皮のポリフェノール）が低酸素誘導因子-1αによるアンドロゲン受容体シグナルの亢進を抑制することで, 去勢抵抗性前立腺がんの増殖を抑制する研究.

CiteScore rank: 150/276 (Medicine), 81/127 (Nutrition and Dietetics)

Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells.
Journal of Nutritional Science and Vitaminology,60(2):122-128 2014(Apr.)
Author: Mitani T., Ito Y., Harada N., Nakano Y., Inui H., Ashida H., Yamaji R.

レスベラトロール（ブドウ果皮のポリフェノール）が低酸素によって誘導される抗がん剤耐性を低減する研究研究.

CiteScore rank: 150/276 (Medicine), 81/127 (Nutrition and Dietetics)

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Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4'-amino-3,5-dihydroxy-trans-stilbene
Journal of Nutritional Science and Vitaminology, 59(4):358-364, 2013.
Author: Ito Y*., Mitani T*., Harada N., Isayama A., Tanimori S., Takenaka S., Nakano Y., Inui H., Yamaji R.　(*Co-first Author)

レスベラトロール（ブドウ果皮のポリフェノール）の標的分子としてCBR1を同定した研究.

CiteScore rank: 150/276 (Medicine), 81/127 (Nutrition and Dietetics)

 

抗酸化物質としてのレスベラトロールの多機能性
ビタミン, 86(12):687-689, 2012.
Author: 三谷 塁一,  原田 直樹, 山地 亮一.
レスベラトロール（ブドウ果皮のポリフェノール）の抗酸化効果だけでない機能性についてまとめた記事です.
 

Coordinated action of hypoxia-inducible factor-1α and β-catenin in androgen receptor signaling.
Journal of Biological Chemistry, 287(40):33594-33606, 2012.
Author: Mitani T., Harada N., Nakano Y., Inui H., Yamaji R.

低酸素誘導因子-1αとβ-カテニンが協調的にアンドロゲン受容体シグナルを活性化する研究

CiteScore rank: 19/72 (Inorganic Chemistry), 170/425 (Biochemistry)

Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.
Biochemical and Biophysical Research Communications, 413(2):201-205, 2011.
Author: Higashimura Y., Terai T., Yamaji R., Mitani T., Ogawa M., Harada N., Inui H., Nakano Y.

 

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment.
Journal of Steroid Biochemistry and Molecular Biology, 123(1-2):58-64, 2011.
Author: Mitani T., Yamaji R., Higashimura Y., Harada N., Nakano Y., Inui H.

低酸素下において低酸素誘導因子-1αはアンドロゲン受容体の転写活性を増強する研究.

CiteScore rank: 32/227 (Endocrinology, Diabetes and Metabolism), 19/115 (Clinical Biochemistry)

A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor.
Bioscience Biotechnology and Biochemistry, 74(9):1965-1968, 2010.
Author: Ogawa M., Yamaji R., Mitani T., Murata Y., Nakao M., Harada N., Nakano Y., Inui H,

 

Involvement of three glutamine tracts in human androgen receptor transactivation.
Journal of Steroid Biochemistry and Molecular Biology, 118(1-2):77-84, 2010.
Author: Harada N., Mitani T., Higashimura Y., Yamaji R., Okamoto K., Nakano Y., Inui H.